primary progressive aphasia

Connected speech markers of amyloid burden in primary progressive aphasia

Introduction Positron emission tomography (PET) amyloid imaging has become an important part of the diagnostic workup for patients with primary progressive aphasia (PPA) and uncertain underlying pathology. Here, we employ a semi-automated analysis of …

Task-Free Functional Language Networks: Reproducibility and Clinical Application

Intrinsic connectivity networks (ICNs) identified through task-free fMRI (tf-fMRI) offer the opportunity to investigate human brain circuits involved in language processes without requiring participants to perform challenging cognitive tasks. In this …

Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review

Primary progressive aphasias (PPA) are neurodegenerative diseases clinically characterized by an early and relatively isolated language impairment. Three main clinical variants, namely the nonfluent/agrammatic variant (nfvPPA), the semantic variant …

Dysexecutive Symptoms in Primary Progressive Aphasia: Beyond Diagnostic Criteria

Primary progressive aphasia (PPA) is a heterogeneous neurodegenerative condition in which the most prominent clinical feature is language difficulties. Other cognitive domains have been described to remain unaffected at the early stages of the …

Relying on procedural memory to enhance independence in daily living activities: Smartphone use in a case of semantic dementia

Relying on procedural memory is a promising approach for interventions that address the cognitive difficulties found in semantic dementia. The aim of this study was to determine if procedural memory could be used to optimise learning of relevant …