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Loss of person-specific knowledge in Alzheimer's disease: evidence from priming

Semantic deficits in Alzheimer's disease (AD) are often more severe for items that are characterized by a unique semantic and lexical association, such as famous people. Whether these deficits are due to the degradation of semantic information or a …

Interhemispheric coupling improves the brain's ability to perform low cognitive demand tasks in Alzheimer's disease and high cognitive demand tasks in normal aging

OBJECTIVE: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects the corpus callosum (CC), which plays a key role in interhemispheric coupling in high-demand conditions. Using 3D callosal measurements and a letter-matching …

The impact of aging on gray matter structural covariance networks

Previous anatomical volumetric studies have shown that healthy aging is associated with gray matter tissue loss in specific cerebral regions. However, these studies may have potentially missed critical elements of age-related brain changes, which …

The role of the left anterior temporal lobe in exception word reading: reconciling patient and neuroimaging findings

Semantic dementia (SD) is a neurodegenerative disease that occurs following the atrophy of the anterior temporal lobes (ATLs). It is characterised by the degradation of semantic knowledge and difficulties in reading exception words (surface …

Lack of semantic priming effects in famous person recognition in Mild Cognitive Impairment

INTRODUCTION: Growing evidence indicates that individuals with Mild Cognitive Impairment (MCI) manifest semantic deficits that are often more severe for items that are characterized by a unique semantic and lexical association, such as famous people …

Music recognition in frontotemporal lobar degeneration and Alzheimer disease

OBJECTIVE: To compare music recognition in patients with frontotemporal dementia, semantic dementia, Alzheimer disease, and controls and to evaluate the relationship between music recognition and brain volume. BACKGROUND: Recognition of familiar …

Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration

Though neuroimaging, pathology and pathophysiology suggest a subcortical and deep cortical involvement in Frontotemporal Lobar Degeneration (FTLD), no studies have comprehensively assessed the associated gray matter (GM) volume changes. We measured …

Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles

Few studies have directly compared the clinical and anatomical characteristics of patients with progressive aphasia to those of patients with aphasia caused by stroke. In the current study we examined fluent forms of aphasia in these two groups, …

The role of the left anterior temporal lobe in the semantic processing of famous faces

Neuroimaging studies on healthy subjects have reported the involvement of the bilateral anterior temporal lobes (ATL) in recognizing known people. While the role of the right ATL in the semantic processing of known people is accepted, it is still …

Sound naming in neurodegenerative disease

Modern cognitive neuroscientific theories and empirical evidence suggest that brain structures involved in movement may be related to action-related semantic knowledge. To test this hypothesis, we examined the naming of environmental sounds in …